Andrea Calogero Trecarichi
Laureato con lode in Medicina e Chirurgia e specializzato con il massimo dei voti in Dermatologia e Venereologia all’Università di Catania. Dottorando di Ricerca in Innovazione Tecnologica in Ambito Biomedico presso l’Università degli Studi di Catania. Partecipo assiduamente ad attività cliniche e di ricerca, interagendo quotidianamente con un ampio numero di pazienti e confrontandomi costantemente con colleghi esperti per aggiornarmi sulle più recenti tecniche diagnostiche e terapie innovative. Mi occupo della diagnosi e del trattamento in pazienti di tutte le età di numerose patologie dermatologiche quali acne, rosacea, alopecia, psoriasi, dermatite atopica, melanoma e carcinomi cutanei, infezioni, malattie sessualmente trasmissibili e molte altre affezioni cutanee. Ho partecipato come relatore a congressi nazionali e sono coautore di diverse pubblicazioni scientifiche su riviste specializzate, inerenti tematiche quali trattamenti innovativi della psoriasi, della vitiligine, dell'alopecia areata e delle infezioni cutanee. Sono membro della società italiana di dermatologia SIDEMAST.
Recent advances in non-invasive imaging technologies have significantly improved the diagnostic approach to inflammatory skin diseases. Among these, Line-Field Confocal Optical Coherence Tomography (LC-OCT) represents an innovative tool capable of providing real-time, high-resolution, three-dimensional images of the skin at a cellular level, enabling a “virtual biopsy” with strong correlation to histopathology. Although LC-OCT has demonstrated promising diagnostic potential across a wide range of dermatological conditions, its application in inflammatory dermatoses remains partially explored, particularly in combination with artificial intelligence (AI).
This PhD project aims to evaluate the role of LC-OCT in the non-invasive diagnosis of major inflammatory skin diseases and to establish a robust clinicopathological correlation between LC-OCT imaging features and histological findings. A cohort of patients affected by inflammatory dermatoses, including psoriasis, eczema, lichen planus, lupus erythematosus, and bullous diseases, will be prospectively enrolled. For each patient, LC-OCT imaging will be performed on a target lesion prior to skin biopsy, allowing the creation of paired datasets for direct comparison between in vivo imaging and ex vivo histopathology.
In parallel, the project aims to explore the integration of AI-based deep learning algorithms for the analysis of LC-OCT images, with the objective of identifying specific cellular and cytoarchitectural patterns associated with different diseases. The combined use of LC-OCT and AI has the potential to improve diagnostic accuracy, reduce the need for invasive procedures, and support clinicians in the differential diagnosis of clinically overlapping conditions.
Overall, this research seeks to validate LC-OCT as a reliable non-invasive diagnostic tool and to lay the foundation for future AI-assisted diagnostic models in inflammatory dermatology, with potential implications for improving patient care and optimizing healthcare resources.
- Trecarichi AC, Amato A, Lacarrubba F, Micali G, Dall'Oglio F. Beard hair response in alopecia areata universalis treated with baricitinib. JAAD Int. 2026 Jan 27;25:84-85. doi: 10.1016/j.jdin.2026.01.003. PMID: 41777696; PMCID: PMC12950359.
- Trecarichi AC, Nasca MR, Lacarrubba F, Micali G, Verzì AE. Enhanced diagnosis of terra firma-forme dermatosis by dermoscopy and line-field confocal optical coherence tomografphy. JAAD Case Rep. 2025 Oct 28;67:205-208. doi: 10.1016/j.jdcr.2025.10.033.
- Musumeci ML, Trecarichi AC, Megna M, Potestio L, Micali G. Efficacy and safety of ixekizumab in psoriatic patients: a long-term real-world retrospective multicentre study from Southern Italy. Clin Exp Dermatol. 2025 Apr 24;50(5):1041-1042. doi: 10.1093/ced/llae519. PMID: 39587384.
- Dall'Oglio F, Trecarichi AC, Nasca MR, Lacarrubba F, Verzì AE, Micali G. The fate of nonscalp hair in alopecia areata universalis under baricitinib treatment: A real-world single-center experience. J Am Acad Dermatol. 2024 Dec;91(6):1208-1211. doi: 10.1016/j.jaad.2024.07.1488. Epub 2024 Aug 9. PMID: 39127133.
- Musumeci ML, Trecarichi AC, Caruso G, Aleo A, Platania H, Micali G. Long lasting response to anti-tumor necrosis factor α agents in psoriasis: A real life experience. Dermatol Ther. 2022 Dec;35(12):e15956. doi: 10.1111/dth.15956. Epub 2022 Nov 1. PMID: 36271708.
- Lacarrubba F, Micali G, Trecarichi AC, Quattrocchi E, Monfrecola G, Verzì AE. New Developing Treatments for Molluscum Contagiosum. Dermatol Ther (Heidelb). 2022 Dec;12(12):2669-2678. doi: 10.1007/s13555-022-00826-7. Epub 2022 Oct 14. PMID: 36239905; PMCID: PMC9674806.
- Musumeci ML, Caruso G, Trecarichi AC, Micali G. Safety of SARS-CoV-2 vaccines in psoriatic patients treated with biologics: A real life experience. Dermatol Ther. 2022 Jan;35(1):e15177. doi: 10.1111/dth.15177. Epub 2021 Nov 15. PMID: 34699117; PMCID: PMC8646328.